Maturation-Promoting Factor

Protein kinase that drives both the mitotic and meiotic cycles in all eukaryotic organisms. In meiosis it induces immature oocytes to undergo meiotic maturation. In mitosis it has a role in the G2/M phase transition. Once activated by CYCLINS; MPF directly phosphorylates some of the proteins involved in nuclear envelope breakdown, chromosome condensation, spindle assembly, and the degradation of cyclins. The catalytic subunit of MPF is PROTEIN P34CDC2.

Also Known As:

Histone H1 Kinase, Growth-Associated; Histone H1 Kinase, Growth Associated; Histone H1 Kinase, M Phase Specific; M Phase Promoting Factor; Maturation Promoting Factor; Mitosis Promoting Factor; Histone H1 Kinase, M-Phase-Specific; M Phase-Promoting Factor; Mitosis-Promoting Factor

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Phosphotransferases: 42769
      - Phosphotransferases (Alcohol Group Acceptor)
        Protein Kinases: 9677
        Protein Serine-Threonine Kinases: 3588
        Proline-Directed Protein Kinases: 28
        Cyclin-Dependent Kinases: 4005
        Maturation-Promoting Factor: 15
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Cell Cycle Proteins: 807
    - Cyclin-Dependent Kinases: 4005
      - Maturation-Promoting Factor: 15
  - Intracellular Signaling Peptides and Proteins: 32
    - Protein Serine-Threonine Kinases: 3588
      - Proline-Directed Protein Kinases: 28
        Cyclin-Dependent Kinases: 4005
        Maturation-Promoting Factor: 15

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Disease

Drug/Important Bio-Agent (IBA)